Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal
Carcinoma—The
Sherry S. L. Kang, B.S. 1,
Skye H. Cheng, MD 1,3, Chao-Ming Huang B.S. 2, James J.
Jian, MD 1, Stella Y. C. Tsai, MD 1, Yih-Lin Chung, MD 1,
Chen-Shou Chui, Ph.D. 2, An-Chen Feng, MPH 3, Andrew T.
Huang, MD 3
1 Department of Radiation Oncology, 2 Department
of Medical Physics , 3 Department
of Research
ABSTRACT
Purpose:
To evaluate the experience at
Patients and Methods:
Between Jan 2003 and June 2005, 210
patients with histologically proven and non-disseminated NPC were treated with
IMRT in our institution. All patients had magnetic resonance imaging (MRI) for
the evaluation of their head and neck tumors. Among them, 93% had concurrent
chemotherapy, and 76% had post-radiation chemotherapy. Of the patients included
in the analysis, male and female ratio was 2.3:1. Seventy-seven percent (77%)
of these patients were of WHO type III histology. Twenty-seven percent (27%)
had T4 disease, and 10% with N3 disease.
Results:
The gross tumor volume (GTV) in
all patients averaged 60.5ml (ranging from1.0 to 339.0 ml). The median dose to
the GTV ranged from 58.2 Gy to 84.7 Gy (median 76.6Gy). On average, V26 of right
parotid glands was minimum 6.5 ml, maximum 46.0 ml and median 19.6 ml, V26
of left parotid glands was minimum 4.0 ml, maximum 44.6 ml and median 18.6 ml.
V60 of brain stem was minimum 0 ml, maximum 1.55 ml and median 0.05 ml.
V50 of spinal cord was minimum 0 ml, maximum 1.53 ml and median 0.07
ml.
Conclusions:
IMRT could deliver more dose to the GTV while reducing radiation dose to critical
organs such as brain stem, spinal cord, parotid glands and inner ears.
Key Words： Intensity
Modulated Radiation Therapy (IMRT), Nasopharyngeal Carcinoma (NPC)
作者姓名：康淑娌
單位：台灣 台北 和信治癌中心醫院 放射腫瘤科 技術長
地址：台灣 台北市北投區立德路125號 放射腫瘤科
郵編：112
聯繫電話：02-28970011轉1336
Email: sherrykang@mail.kfcc.org.tw
Address Correspondence ：
1. Sherry S. L. Kang（Chief Tech. of Department of
Radiation Oncology）
Email: sherrykang@mail.kfcc.org.tw
2.Dr. Skye H. Cheng （Chief of Department of Research）鄭鴻鈞 放射腫瘤科醫師暨 臨床研究室 主任
Email: skye@mail.kfcc.org.tw
Department of Radiation Oncology,
Tel.: 886-2-28970011 ext. 1336
Fax: 886-2-28972233
Running title： Intensity Modulated Radiation Therapy (IMRT) for
Nasopharyngeal Carcinoma—The Koo Foundation Sun Yat-Sen Cancer Center
Experience